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Bio-Plus Capsules


Sweet-Itch also known as Queensland Itch is a distressing condition which affects about 10% of UK horses, donkeys and ponies, sometimes making them un-rideable and in severe cases they are put down.  It is a recurring yearly condition which peaks in the late summer as the midge population increases and until the development of Bio-Plus capsules the only commonly available option was to cover up and apply ointments to help reduce the inflammation




A study in 2008 involved 135 horses of which 11.1% showed a complete absence of the condition, another 69% showed an improvement of 50% or more and only 4.4% did not respond at all.   In the great majority, improvements between 20% and 80% were recorded.   These results were very similar to those recorded in the 2007 study and in the later 2009-2011.

Many owners reported that although the symptoms had not completely resolved the horse had a much improved demeanour and could be ridden throughout the season.




Bio-Plus capsules contain a bio-protein listed under EU Regulations (EC) 767/2009,  FEFAC Product code EN-01462/3.  Composition, 2mg of bacterial protein derived from the fermentation of  heat killed cells of the actinomycetales species Tsukamurella inchonensis; mean crude protein 70%. Carrier excipients; trehalose sugar 80%,  potato starch 20% & Sipernat less than 0.05%.  Capsule shell; gelatin derived from non-animal sources. Contra indications; none



Bio-Plus is Patent protected in the EU, the USA and most other major jurisdictions in Europe and the Far East.  Any abuse of these Patents by way of unauthorised passing-off or the production or marketing of parallel products or products having a composition of a like nature is prohibited.




Possibly as a result of selective breeding and changes in animal husbandry, some animals became less well adapted to fight off diseases and allergies.  Bio-Plus reagents belong to a family group of ‘immune modulators’  which work by sending signals to the immune system of the host animal to respond more efficiently. These immune modulators are cultured from naturally occurring bacteria, belonging to a group of bacteria including Mycobacterium and a number of environmental genera of actinomycetales which have a proven track record in the treatment of many human conditions such as TB & cancers and in other animals such as flea allergies in dogs. It would be reasonable to expect beneficial changes in other allergic phenomena, such as recurrent airway obstruction (RAO) and chronic obstructive pulmonary disease (COPD). In a number of cases animals with both sweet-itch, RAO and COPD have been found to show benefits in these conditions.



Veterinary Science
  • Sweet-itch is caused by allergy to substances in the saliva of Cullicoides midges resulting in a chronic inflammatory response,  causing distress and resulting in self-inflicted damage in the affected animal.

  • The IgE-mediated response to individual midge bites results in minor local tissue damage resulting in expression of stress proteins on the cells. In animals developing sweet-itch there is then a delayed Th2- mediated autoimmune response to the cells expressing these stress proteins leading via the pathway of chronic inflammation to tissue necrosis, granuloma formation and ulceration.

  • Immune modulators  address the delayed part of the response by switching off the Th2 mechanism and replacing it with Th1 response resulting in removal of the cells expressing stress proteins without tissue necrosis. Additionally by down-regulating Th2 cytokine production (notably IL-4 and IL-5) the production of IgE is reduced, calming the initial allergic response to the midge bites.





          To order and for more information please visit


            Capsules are available in supplies of 3, 6 or 12 months


            The order will be charged in Brittish Pound £ and shipped to you from the UK



             At checkout, enter BOETT USA in the message box for free shipping to the US





















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